Meeting Banner
Abstract #3181

3D DP-FISP for Diffusion Measurements in MR Microscopy at Ultra-High Field.

Ileana Ozana Jelescu1, Denis Le Bihan1, Luisa Ciobanu1

1NeuroSpin, Gif-sur-Yvette, Essonne, France

A 3D diffusion-prepared fast imaging with steady-state free precession (DP-FISP) sequence was implemented at 17.2T to perform apparent diffusion coefficient (ADC) measurements in small biological samples (i.e. single cells). The sequence was tested on phantoms with different T1s, including values similar to those of biological tissues, and was compared with a standard diffusion-weighted spin-echo (DW-SE) sequence. The FISP flip angle was optimized for minimal T1 bias in ADC estimation (< 10%) for b-values up to 600 s/mm. Our sequence is less prone to artifacts than EPI and eight times faster than DW-SE. Future improvements include extension to higher b-values.

Keywords

acceptable accounts acquisition acquisitions adapted aimed allowed allows amount apparent appears aqueous artifacts artificial audience benefits best bias biological brings capillaries cell cells cellular centric choice chosen closely collects compromise confidence consisted contained corrupted critical diffusion displays doped eddy efficient employed encoding equivalent error establishment evaluated expected experience explored extreme fast field fields fits free functional glass going gold good hand hence highest homebuilt homogeneous identical improvement in vivo introduce introduced isolated isotropic issue latter linear longitudinal magnetization mainly manganese match matrix measured mechanical microscopy minimization modalities module necessary need negligible neurons noise nonetheless nuclear optimized performance perturbation phantom phantoms plays precession preparation prepared previously probably program prone prove rapid read readout recommendation recovery reduced render resolution resolutions respectively robust role samples schematic severe slice solutions spatial steady storing strategies suitable suited susceptibility table take taken target term terms timings toward transceiver translates typical ultra underestimates underlining various viability vibration view water worth