Meeting Banner
Abstract #3019

Associating Neuropsychological Deficits with Decreased Gray and White Matter Density in Alcohol Dependents: A Voxel Based Morphometric Analysis Using DARTEL

Deepika Bagga1, Namita Singh1, Shilpi Modi1, Prabhjot Kaur1, Debajyoti Bhattacharya2, Mohan Lal Garg3, subash khushu1

1NMR Research Centre, INMAS, New Delhi, India; 2Department of psychiatry, Base Hospital, New Delhi, India; 3Department of Biophysics, Panjab University, chandigarh, India

Chronic alcoholism leads to a number of transient or persistent neurological and psychiatric deficits. The aim of our study was to associate the cognitive deficits observed in visuospatial information processing as assessed by PGIBBD (PGI-Battery of Brain Dysfunction) in alcohol dependents with the brain morphometry changes and duration of alcohol consumption. To that end, VBM analysis was carried out in alcohol dependents and healthy controls. Significant gray and white matter volume loss in fronto-parietal regions was observed which could account for the impaired visuospatial information processing skills in alcohol dependents.

Keywords

abilities abstained abstinent abuse affected aimed alcohol alcoholic alcoholics alcoholism algebra altered although assesses associating association attributed audience battery behavior bilaterally biophysics body brain carried channel chronic citation cognitive coil conducted consistently consumption contribute controls corporation correlated decreased deficit deficits density dependence dependent dependents detoxified drinkers drug duration dysfunction education examination exponentiated extends field findings frontal functioning functions gradually gray growing handbook handedness head health healthy hemisphere impaired impairments inferior intelligence leads least literature lobe lobule looking loss matched material middle might mild namely national neurological parietal parsons part perception performance period preserved primarily processing prominent psychiatry psychological psychosocial rating recognition reduction reflect regional registration relatively rendered researchers resolution responsible retention review scale score scores selective severe severely shrinkage since skills smokers sober social software spared spatial structural studies subjects substantial subtest suggests superior system table taken target temporal verbal version view visual volume volumes week whereas white whole world years