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Abstract #2990

Brain Plasticity Changes in Motor Region and Dynamic Changes in White Matter After Stroke Induced by a Neural Activity-Triggered Rehabilitation Device

Jie Song1, Leo Walton2, Brittany Young2, Veena A. Nair3, Svyat Vergun4, HuiChun Chen5, Dorothy Farrar-Edwards5, Mitch E. Tyler1, Justin Sattin6, Justin C. Williams1, Vivek Prabhakaran3

1Biomedical Engineering, UW-Madison, Madison, WI, United States; 2Neuroscience Training Program, UW-Madison, Madison, WI, United States; 3Radiology, UW-Madison, Madison, WI, United States; 4Medical Physics, UW-Madison, Madison, WI, United States; 5Kinesiology, UW-Madison, Madison, WI, United States; 6Neurology, UW-Madison, UW-Madison, WI, United States

We investigate a closed-loop neurological feedback device which combines Brain computer interface-EEG and functional electrical muscle stimulation together with tongue stimulation and combines the subjects intention-to-move with the stimulated output thus providing patients with both visual and sensory feedback and direct control of the stimulus intensity. We use fMRI and DTI to elucidate the neural mechanisms by which the training with this device can facilitate brain reorganization and white matter change leading to greater functional recovery.

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Keywords

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