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Abstract #2965

Metabolic and Structural Correlates of Different Patterns of White Matter Injury in Preterm Infants

Ashok Panigrahy1, 2, Jessica L. Wisnowski1, 3, Rafael C. Ceschin4, Stefan Bluml2

1Pediatric Radiology, Childrens Hospital of Pittsburgh, Pittsburgh, PA, United States; 2Childrens Hospital Los Angeles, Los Angeles, CA, United States; 3Brain and Creativity Institute, University of Southern California, Los Angeles, CA, United States; 4Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

We used MRS to examine cerebral metabolism in the parietal white matter of a large cohort of high-risk preterm infants in relation to two MRI defined patterns of white matter injury and present the first evidence of altered NAA/MI ratio, T2 relaxation, and thalamic volume, in association with punctate white lesions, but not diffuse extensive high signal intensity (DESHI)

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Keywords

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