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Abstract #2921

Incorporating ADC Temporal Profiles to Predict Ischemic Tissue Fate in Acute Stroke

Qiang Shen1, Virendra Desai1, Timothy O. Duong2

1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States

Acute diffusion data has been used to predict ischemic tissues fate on a pixel-by-pixel basis. Predictions however were made based on acute MRI data from a single time point. This study proposes a novel approach to incorporate the temporal characteristics of acute ADC (apparent diffusion coefficient) changes to characterize tissue fate based on a pixel by pixel basis. This approach was tested on rat stroke models subjected to permanent, 60-min and 30-min middle cerebral artery occlusion (MCAO). We concluded that there were distinct temporal patterns that determined tissue salvageability and incorporating temporal information can improve prediction accuracy.

Keywords

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