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Abstract #2918

Imaging of Tissue pH Response to Oxygen Therapy in a Rodent Model of Acute Stroke

Phillip Zhe Sun1, Yu Wang1, Jie Lu2, Xunming Ji2, Eng H. Lo3

1Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Radiology, Xuanwu Hospital, Beijing, China; 3Radiology and Neurology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States

Normobaric oxygen (NBO) treatment is a promising treatment strategy that may mitigate ischemic tissue damage. However, the mechanisms of NBO therapy are poorly understood, elucidation of which may assist development of more effective combinational treatment. Given that pH is a surrogate tissue metabolic marker, our study applied pH imaging to evaluate the emerging NBO treatment. Our pilot study found that whereas penumbral tissue showed pH recovery upon initiation of NBO therapy, its pH degraded significantly after the termination of NBO. Our pilot data suggest that NBO may transiently relieve ischemic tissue injury, and reperfusion is needed for long-term outcome improvement.

Keywords

acidic acidosis acute addition adequate aerobic amide anaerobic animal approved artery asymmetry available biomedical black blood blue bore brain cascade caused cerebral challenge characterize characterized chemical china collapsed combinational committee commonly complementing complex conducted core decrease decreased deficit deficits delivery developed diffusion displayed displaying dosage duration efficacy elucidate ethics evaluate exchange expected flow future guidelines hypothesize immediately importantly improvement induced induces injury institutional interestingly inversion labeling lesion little long male manually mapping materials metabolic middle mildly minor mismatch mitigate model molecular monitoring native necessary needed negligible neurology nevertheless notably note novel nutrient optimal outcome outlined oxygen oxygenation parametric particularly penumbra perfusion permanent pilot poor promising quantitative radiology rats readily recently recovered recovery remains representative resolution respect response reversed rodent saturation scanner secondary severe severely side similarly slightly spillover status stroke structural suffered suffers sufficient suggests summary term termination therapy tissue tool transfer transiently treatment unaltered undergoing unique upon weighed whereas window