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Abstract #2872

Age-Dependence of Hemodynamic Response Characteristics in Human FMRI

Claudine Jolle Gauthier1, 2, Ccile Madjar3, 4, Laurence Desjardins-Crpeau3, 5, Pierre Bellec3, 6, Louis Bherer, 37, Richard D. Hoge2

1Neurophysics, Max Planck Institute for Cognitive and Brain Sciences, Leipzig, Saxony, Germany; 2Physiology, CRIUGM/Universit de Montral, Montreal, Quebec, Canada; 3CRIUGM, Montreal, Quebec, Canada; 4Montreal Neurological Institute, Montreal, Quebec, Canada; 5Psychology, UQAM, Montreal, Quebec, Canada; 6Computer Science and Operations Research, Universit de Montral, Montreal, Quebec, Canada; 7Concordia University, Montreal, Quebec, Canada

The BOLD signal is often used as a direct index of neuronal activity to study changes with aging. However, profound changes in cerebrovascular properties in older adults may lead to biases in the interpretation of BOLD signal differences between young and old. Here we show that changes in baseline blood flow, reactivity to hypercapnia and calibration parameter M are present even in healthy aging. These changes may lead to underestimation of metabolic changes with aging.

Keywords

account acquisition acquisitions activation activity additional adults aging ambiguous amplitude anatomical anterior arise arterial assumed assumption automatic averaging behavioral believe bias biases blocks blood bold brain calibrated calibration cerebral characteristics cognition cognitive complicates computer concomitant conditions consisted context contrast control cortex cortical coupling covering decreased delay dependence dependent determined direct dual duration erroneous especially even evoked exercised explore extent fact female flow frontal function functional generalized generally healthy included incorporating index indicate inferences institute intersection inversion known lead lesions life lifespan lobes local localize made make makes making maps mask matrix metabolic metabolism model modified must neurological neuronal occur older operations oxidative oxygenation participants percent performance physiologically physiology pooled post providing pseudo psychology quantitative readouts reason related resources response responses rest revealed review runs science sciences segmentation separated sessions severity significantly slices sources stems stimulation structures studies suspected system taken task tasks thought tidal tissue typically vascular white years young younger