Meeting Banner
Abstract #2865

CSF Biomarkers Associate with GM Volume and Brain Microstructural Changes Mainly from Default Mode Network in Alzheimers Disease

Xiaozhen Li1, Tie-Qiang Li2, Niels Andreasen3, Maria Kristoffersen Wiberg4, Eric Westman1, Lars-Olof Wahlund1

1NVS Department, Karolinska Institutet, Stockholm, Sweden; 2Department of Medical Physics, Karolinska Institutet, Stockholm, Sweden; 3Alzheimer Disease Research Center, Karolinska Institutet, Stockholm, Sweden; 4Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden

Alzheimers disease (AD) is the most common dementia in elderly people. The pathological hallmark of AD is amyloid plaques and neurofibrillary tangles, which are made up of Aβ42 and p-tau, respectively. Decreased levels of Aβ42 and increased levels of total tau protein (T-tau) and p-tau in CSF are useful and valid tool for the diagnosis and prognosis of AD. In this study, we investigated the correlation between AD CSF biomarkers and grey matter volume and brain microstructural changes using VBM analysis and DTI measurement.

Keywords

adjusted arch axial beneficial better biochemical body brain calculation channel clinical cluster cognitive coil common consistent corrected correction correlation datasets decades decreased default dementia dementias demographic deposition detected development diagnose diagnosis diffusion diffusivity disease distortion early eddy emission entered eventual evidence findings fluid forming fractional frontal full gender gradients hallmark head help hemisphere impairment include included indicating individual inference intervention investigated investigation involved lobe lumbar made mainly majority maps maria mask materials measured medical mild mode moreover motion negative network occipital occur orientations output overlap parietal part participants particular pathological pathology patients people permutation permutations physics plaques position positive positron prior processing profile prognosis program progression protein protocol puncture randomize recognized reflected registered related resolution respectively reveal sample scanner science segmented sensitizing severe slices smoothed stage stages structure studied subjective subjects suggested summary support table technology template temporal threshold tomography tool understand understanding underwent useful volume white whole widespread width wise