Meeting Banner
Abstract #2857

Assessing Regional Gray and White Matter Changes to Understand the CNS Related Symptoms of Myotonic Distrophy Type-1

Marco Bozzali1, Laura Serra2, Barbara Span2, Mario Torso2, L Lispi3, A Rosini3, S. Costanzi-Porrino3, M. Giacanelli3, Carlo Caltagirone4, A Petrucci3

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 3Neurology and neurophysiopathology Unit, "San Camillo Forlanini" Hospital, Rome, Italy; 4Neurological and behavioural Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy

This voxel-based morphometry study investigates associations between regional grey (GM) and white matter (WM) volumes in patients with genetically confirmed Steinert disease (SD). Interesting associations between GM and WM atrophy, and clinical and neuropsychological features were found, which contribute to clarify some pathophysiological aspects of CNS involvement in SD.

Keywords

abnormalities account acquisitions adding aims already analyses anterior assess assessing assessment association associations atrophy battery bilaterally brain carriers central cerebellum clinical cluster cognitive confirmed confirms conflicting considered controls correction correlation correlations covariate cranial deficits design diagnosed diffusion direct disorders dominant dominated driven dual dysfunctions dystrophy efficacy entered equilibrium examination executive expansion explore exploring extension extensive fast features finally flair foundation framework frequent frontal functions gene general genetic genetically genetics gray healthy hospital impairment includes intra inverse investigated involvement kernel laboratory laura likely linear lobule loss maps matched matrix measures mechanisms might model modified morphological muscle muscular mutation neurological neurology participants particular patients performance picture pons post posterior potential presence processed produced protocol psychiatric ranging rating recruited regional regression related respectively revealed sample scale score scores served sixteen slices statistical statistics strict subjects suffering survived symptoms tissue torso trait transform transmitted triplets turbo type understand underwent unit volume volumes volumetric white widespread