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Abstract #2853

An Investigation of Functional Connectivity in the Inhibitory Control Network in Prodromal Huntington's Disease

Katherine A. Koenig1, Stephen M. Rao2, Mark J. Lowe1, Jian Lin1, Deborah L. Harrington3, Dawei Liu4, Ken E. Sakaie1, Jane S. Paulsen5

1Imaging Sciences, Cleveland Clinic, Cleveland, OH, United States; 2Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; 3Research, Neurology, and Radiology Services, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States; 4Department of Biostatistics, The University of Iowa Carver College of Medicine, Iowa City, IA, United States; 5Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA, United States

The current study used a seed-based approach to examine resting state functional connectivity in the inhibitory control network in prodromal Huntington Disease. Our findings indicate that connectivity patterns are disrupted in the prodromal stages of HD, particularly to areas involved in task attention and motor intention.

Keywords

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