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Abstract #2847

Functional Connectivity in Patients with Progressive Sopranuclear Palsy Is Modulated by Cerebellar Intermittent Theta Burst Stimulation

Chiara Mastropasqua1, 2, Marco Bozzali3, Viviana Ponzo4, Mara Cercignani, 15, Carlo Caltagirone6, 7, Livia Brusa8, Giacomo Koch4, 9

1Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy; 2Department of Neuroscience, Trieste University, Trieste, Italy; 3Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 4Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia, Rome, Italy; 5Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, Falmer, United Kingdom; 6Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; 7Dep. of Neuroscience, University of Rome Tor Vergata, Rome, Italy; 8Dep. of Neurology, S. Eugenio Hospital, Rome, Italy; 9Stroke Unit, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy

Progressive Sopranuclear Palsy (PSP) is a degenerative parkinsonism clinically characterized by postural instability and sopranuclear gaze palsy. Repetitive Transcranial Magnetic Stimulation (rTMS) shows promising results when used as a therapeutic tool. We investigated the impact of cerebellar iTBS on Functional Connectivity (FC) in a group of PSP patients comparing Resting State fMRI, before and after iTBS treatment.We found a bilateral increase in FC in the caudate nucleus and in left parietal cortex, and a FC reduction in the right precuneus, after iTBS treatment. Our study provides new evidence that iTBS is able to induce modifications of FC in PSP patients.

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Keywords

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