Meeting Banner
Abstract #2697

Z Spectral Analysis for the Quantification of Multiple Slow-Exchanging Metabolites

Kejia Cai1, Anup Singh1, Mohammad Haris1, Ravi Prakash Reddy Nanga1, Ranjit Ittyerah1, Damodar Reddy1, Harish Poptani1, Hari Hariharan1, Ravinder Reddy1

1University of Pennsylvania, Philadelphia, PA, United States

This conventional quantification method may be confounded by the intrinsic magnetic transfer ratio (MTR) asymmetry as well as the Nuclear Overhauser Effect (NOE) effect. To decouple these confounding effects, we demonstrate a comprehensive Lorentzian fitting of Z spectra in brain tumor for the quantification of multiple slow-exchanging metabolites contributing to Z spectrum acquired with low RF saturating amplitude. Results show an increased amide proton transfer (APT) integral and a decreased CEST integral at 2ppm in tumor compared to normal brain tissue. The novel Z spectral analysis method may be used for differentiating tumor metabolic profile from normal tissue.

Keywords

according acquisition adjusted amide amplitude animal appear approved arises assistance asymmetry authors basis bottom brain care cartilage cell central chemical clearly column committee comparing component components comprehensive concentration confounded confounding constrained continuous contrast contributing contributions contributors cranial decouple developed differentiating direct elevated enlarged entire especially except exchanging fast field fine fisher fitted fitting five flash flipped functions glutamate glycogen grant green hydrocephalus hydroxyl indicates initials inoculation institutional integral intra intrinsic lasting ling liver located loosely magnitude major mapping maps medicine metabolic metabolites mostly narrower natl nature negative nonlinear normalized novel nuclear peak peaks pixel pixels pool post previously probably profile project proposed protocol protocols proton protons pulse pulses quantification quantifying rats readout recent recently reduces relatively remaining reported respectively reveals round routine saturating saturation shot side slice slow spectra spectral spectrum subtracted supported thank tissue transfer tumor tuned tuning usually variation vary ventricle water wave week weeks width widths