Meeting Banner
Abstract #2530

Contamination of Neurometabolite Amine-Water Proton Exchange to Amide Proton Transfer MRI

Xiaopeng Zong1, Ping Wang1, Seong-Gi Kim1, Tao Jin1

1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Amide-water proton transfer (APT) can be exploited to provide useful MRI contrast under various disease conditions. However, the APT-weighted signals (APTw) might be contaminated by other chemical exchange processes, such as fast amine-water proton exchange. To investigate this issue, we measured APTw of nine major neurometabolites in phantoms and estimated their contributions to the <I>in vivo</I> APTw contrast in ischemic rat brain. We found significant contributions from several metabolites to the APTw, which showed pH dependence opposite to the APTw signal <I>in vivo</I>. Thus, possible contaminations from neurometabolites should be considered when interpreting the sources of APTw contrast.

Keywords

acid acquisition although amide among animal applications approval assuming audience away backbone become black brain brains buffered care cerebral chemical chloride close coils committee concentration concentrations conditions considered consistent contains contaminations contra contrast contrasts contribute contribution contributions control darkening denote dependence despite detected deviations diameter disease doped duration earlier especially exchange exchanging exciting experiment explained exploited fact fast frequency glutamate hemisphere important in vivo induce induced institutional interpreting investigate issue journal lactate largest lesion lied linear localized magnetization major male maps marked maximal measured medicine metabolite metabolites might mode negligible nine observations occurring offsets onset opposite pathological permanent phantom phantoms ping planar power preparation prepared produce proton protons pulse quantification radiology rats reduced relationship relies respectively saline saturation shortening side sides significantly sixteen slow slower solutions sources spectra spectroscopy spin square steam stimulated stroke studied studies suggests suppressed surface system table target temperature theoretical tissues transfer true underlying volume water wave weighing whose