Meeting Banner
Abstract #2513

Quantitative Proton Density Mapping in Pathological Tissue: Comparison of Two Receiver Profile Correction Methods

Steffen Volz1, Ulrike Nth1, Alina Jurcoane2, Ulf Ziemann3, Elke Hattingen2, Ralf Deichmann1

1Brain Imaging Center, University Frankfurt, Frankfurt, Germany; 2Department of Neuroradiology, University Frankfurt, Frankfurt, Germany; 3Department of Neurology, University Frankfurt, Frankfurt, Germany

Correcting for the receiver profile (RP) of the RF coil is a crucial step in quantitative proton density (PD) mapping. Two new RP correction methods were compared for pathological tissue: (1) bias field correction method and (2) pseudo PD calculation method assuming a linear relationship between T1 and PD in white and grey matter. Results were consistent for multiple sclerosis and stroke patients (small lesions). However, differences between the two RP correction methods were found in tumour tissue with results from the pseudo PD method being more plausible.

Keywords

accessed according acquisition additionally advantage amounted applicability applied array assuming automatically avoiding beyond bias body bottom brain calculation channel coil coils complex comprising consisted constant contrast contrasts correcting correction correspond coverage created crucial delineation density depicted described detail directly edema either erroneous excluded extend extended fact field flair flash generated good head healthy histograms human hybrid hyper identical imposed inside intense intensity interpolation investigated isotropic lesion lesions like linear literature making mapping maps mask materials mentioned middle nearly neurology normalizing often pathological patient patients plausible polynomial pooling post preferable presence probably problem processing product profile profiles proposed protocol proton pseudo quantitative quotient readout realized receive receiver reception reciprocity relationship removes represent resolution respective respectively sample scanner sclerosis segmentation semi sensitivity slice spoiled strengths stroke subjected subjects subsequent suffering summary systematically theorem tissue transmission usually variable ventricles whereas white whole yield yielding yields