Meeting Banner
Abstract #2502

Correlation of R2 and R2* with Quantitative Susceptibility Maps in Healthy Elderly Controls

Jeam Haroldo Oliveira Barbosa1, Saifeng Liu2, Jin Tang3, Manju Liu4, Weili Zheng4, Ewart Mark Haacke2, 4, Carlos Ernersto Garrido Salmon1

1Department of Phisics, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil; 2School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 3MRI Institute for Biomedical Research, Detroit, MI, United States; 4Wayne State University, Detroit, MI, United States

There are a variety of means by which iron content in vivo tissue can be measured. These include but are not limited to measuring: transverse relaxation rates (R2 and R2*) and quantitative magnetic susceptibility (QSM). However, the dependency of transverse relaxation rates with water content can confound the accuracy of iron quantification if R2 or R2* are used. To overcome this limitation, magnetic susceptibility mapping has been suggested to evaluate iron deposits in neurodegenerative diseases. In this study, we evaluated the correlation between iron concentration with R2 and R2* and magnetic susceptibility in vivo in the midbrain region for seven healthy elderly subjects.

Abstract PDF Poster PDF

Keywords

accuracy affect agreement allow almost appear applied authors axial background basal best biomedical brain bulk cadaver certain close coefficient concentration concordance confound consider content contributions controls correlation create created creating dependency deposits diseases dispersion distribution draw drawn echoes elderly engineering equally estimation evaluate evaluated example except exponential extract field filter former function ganglia generate gray healthy herein highest hospital implemented in vivo include influence influenced institute introduced iron just known latter likely limitation limited linear mapping maps mark martin mask maybe measured measuring mechanisms mono nature neurology nucleus orientation orientations overcome potentially problems procedure processed proportional quantification quantitative quite radiology radius recent recognized recruited referred regularization regularized related remove reported reports representing resolution respect restricted resultant reveals salmon scanner school sensitive sensitivity seven several sharp sinuses slices slope smart sources spaced spin subject subjects suggested suggesting susceptibility swim tang thalamus tissue tool transform transverse turbo unwrapping variety version water white years