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Abstract #2433

Quantification of Aortic Stiffness Using MR Elastography and Its Comparison to Pulse Wave Velocity: Early Validation

Aniurdh Damughatla1, Brian Raterman2, Orlando P. Simonetti2, 3, Travis Sharkey-Toppen4, Ning Jin5, Richard White2, Arunark Kolipaka2, 3

1Biomedical Engineering, The Ohio State University, Columbus, OH, United States; 2Radiology, The Ohio State University, Columbus, OH, United States; 3Internal Medicine, Division of Cardiovascular Medicine , The Ohio State University, Columbus, OH, United States; 4Davis Heart & Lung Institute, The Ohio State University, Columbus, OH, United States; 5Siemens Medical Solutions, The Ohio State University, Columbus, OH, United States

In aortic aneurysm or Marfan syndrome the stiffness of the aorta varies spatially, however clinical techniques provide global measure of stiffness. Therefore, there is a need for spatial estimation of stiffness of aorta non-invasively. The purpose of the study is to compare the abdominal aortic stiffness obtained using MRI based pulse wave velocity (PWV) measurements against magnetic resonance elastography (MRE) based stiffness measurements in normal volunteers with increase in age. The MRE stiffness values and PWV values plotted against age resulted in similar correlation in the in initial pool of data demonstrating initial feasibility in the same imaging plane.

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Keywords

abdominal accelerate actively ages aging among anal analyzed aorta aortic applied arterial arteries artery assessment audience biomedical built cardiac cardiology cardiovascular causes clinic clinical common comparing computers conditions conjunction contour contours contribute coronary correlation currently custom demonstrating derived detection determination determine developed disease diseases displacements distance diver division early encoding engineering establish even example feasibility foot function furthermore global gold gradient head health healthy heart house hypertension hypertensive important in vivo included increasing independently individual institute introduced invasive known linear lung magnitude major management many maps masked matrix mayo measure mechanical medical medicine modalities motion novel outcomes patient patients people physicians placed plays plot plotted pneumatic portion position positioned process propagating propagation pulse quantification radiology recently recognized represents researchers risk role scanner segmenting shot shots significantly similarly slice slope snap software solutions spatial stiffening stiffness studies supine target technologists tracked trio utilized validation various velocity volunteer volunteers warranted wave waves whereas white years