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Abstract #2330

Evaluation of the Validity of Task Switching Paradigm as a Cognitive Stress Test

Mitsunobu Kunimi1, Sachiko Kiyama2, Toshiharu Nakai2

1National Center for Geriatrics and Gerontology, Obu, Aichi , Japan; 2National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

We attempted to evaluate the validity of divalent Task Switching Paradigm (TSP) as a cognitive stress test. Fifteen young and 15 elderly volunteers participated. The brain areas with augmented brain activation depending on the difficulty of TSP task were different between the two age groups. In particular, it was observed that the contrast of Elderly against Young of right caudate nucleus and hit rate score was significantly correlated with the activation in the right caudate nucleus in the Elderly. Evaluation of the activation in the caudate nucleus using TSP may be valid to represent the aging effects on reconfiguration function.

Keywords

activation activations activity acuity addition affected aging analyzed applied appropriate assume attempted augmented axial behavioral blocks blue bold brain cerebellum checked choose clinical cluster cognitive color comparing complex condition conditions conducted continuously contrast correlated correspond daily decline demands dependent depending depends detect detected diagnosis difficulty divalent domain downer elderly evaluate evaluation examination extent frontal function functional geriatric geriatrics gerontology goal goals gradient habit healthy highly hypothesis inferior influence informed interaction interval japan judgment known learning life lobule location making males material medial memories memory mental middle mini minus national normalized nucleus objectively occipital paradigm parietal participants particular pattern peak performance periodically phenomenon pole posterior potential process propose realigned recognition reconfiguration related required rest revealed rules sample scale score series shape significantly since slices speed square status stimuli stress strong strongly subjects suggested superior switch switching system table task tasks temporal thick trends uncorrected validity variable velocity view viii visual volunteers young