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Abstract #2322

Exploring the Mouse Brain Functional Networks After Demyelination: A rs-fMRI Study

Neele Saskia Hbner1, 2, Anna Mechling1, Hsu-Lei Lee1, Jrgen Hennig1, Dominik von Elverfeldt1, Laura-Adela Harsan1

1Department of Radiology - Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 2Faculty of Biology, University of Freiburg, Freiburg, Germany

This study demonstrates the potential of resting state functional magnetic resonance imaging for investigating the mouse brain functional networks in normal and pathological conditions. We investigate the impact of experimentally induced demyelination on the functional connectivity of cuprizone demyelinated mice. Data derived from independent component analysis combined with partial correlation analysis and graph theory indicate a complex remodeling of the large scale functional networks in the mouse brain as an effect of demyelinating pathology.

Keywords

abbreviations acquisition activation adapted alterations animals assigned atlas barrel bilateral binary biology body bootstrapping brain calculating capsule centrality chronic clustering compensatory complex component components conditions connections connectivity considered control controls coordinating corpus correct correlation cortex cortical courses datasets decreased degree detected development disorders distinct done established evaluate examination examples excluding experimentally fashion fine franklin functional generated graph graphs great half head highest housing identification identified identify increasing independent indicating induced influential interacting interlaced kept knowledge laura loss mapping material matrices mechanisms medical mice model moderate modifications module modules motion motor mouse networks neurology node nodes nuclei oxygen parametric partial pathological pathologically pathology patterns positive potential precise preprocessed profile radiology realignment recorded relevant remodeling repetitions reproducibility respectively response resting runs saturation scale scanned scanner sclerosis sedation separately severe smoothing stability statistically strength strengths suggesting supplementary system systems temperature theory tool toolbox translational treated treatment tuning twelve underlying valuable visual volumes week weeks