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Abstract #2264

Magnetic Resonance Imaging the Genetic Influence on Intrinsic Resting-State Connectivity in Brown Norway and Dahl Salt-Sensitive Rat Brains

Zhixin Li1, B. Douglas Ward2, Melinda R. Dwinell3, Christopher P. Pawela1

1Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, United States

We address for the first time the genetic influences on intrinsic neural connectivity in a resting-state fMRI study of two genetically different inbred rat strains:Brown Norway(BN) and Dahl salt-sensitive(SS) rats.SS rat exhibited differential intrinsic functional connectivity patterns in primary somatosensory and caudate putamen network in comparison to BN rats. These task-specific regional differences in neural network can speculatively suggest an endophenotype or imaging marker of genetic component of under specific biological events.

Keywords

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