Meeting Banner
Abstract #2161

Dual Slice Perfusion Measured with PASL-SIR

Erin K. Englund1, Michael C. Langham1, Cheng Li1, Felix W. Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

In this work, a traditional pulsed arterial spin labeling (PASL) technique is combined with simultaneous image refocusing (SIR) EPI readout to measure dual-slice perfusion in the leg. PASL-SIR is evaluated by comparing results acquired in the two slices to an otherwise identical single-slice PASL sequence during a series of ischemia reperfusion paradigms in the leg. Time course parameters for the dual-slice PASL-SIR technique are in relative agreement with single-slice-measured perfusion and with literature reported values. Implementation of PASL-SIR in longitudinal studies may improve reproducibility by reducing errors due to subject repositioning.

Keywords

accurately achieved acquisition addition additional allow allowing altered anterior appearance arrow arterial artery blood blue bottom caffeine called capable considered consistent correlates course coverage covering cuff delays delivery described despite determine determined deviation diagram disease dotted dual echoes errors evaluate example excites exist experimental exploration fair feasibility flow gradient grants green healthy hence hydration hyperemia hyperemic hypothesis hypothesized improvements increasing indicates inferior inflated inflation initial insight interpolation inversion inverts investigate label labels linear location locations longer longitudinal magnetization many matching matrix measure measured muscle must needed normalization nutrients occasion occlusion overall oxygen paradigm paradigms partial peak perfusion period physiologically pneumatic post previously prolongs pulse pulses quantification quantified quantifies radiology reactive readout reconstructed recovery reducing refocusing reported reporting repositioning reproducibility require resolution response scanned scheme selective separate separated series several severity simultaneously skeletal slice slices solid star subject subtracted table tagging temporal tissue tourniquet twice typical varies whether width yellow yields young