Meeting Banner
Abstract #2042

Simultaneous Detection of 17 Brain Metabolites at 3T by JPRESS & ProFit

Alexander Fuchs1, Peter Boesiger1, Anke Henning1, 2

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Max Plank Institute for Biological Cybernetics, Tbingen, Germany

In-vivo data acquired at 3T and simulated 2D JRPESS spectra were used to test and validate the new version of the ProFit fitting tool. The results indicate the potential to reliable fit up to 17 brain metabolites with CRLBs below 20%.

Keywords

according accordingly acetate achieved added additional additionally address agreement allows applying approximate arbitrarily axis bars basis bingen biological biomedical blue brain called clinical coefficients coil combined common concentration concentrations consequence content contribution correlation cortex defined described detection developed deviation dimension dimensional dimensions direct distorted eight enables envelopes essential exceeded excellent except extended fitted form frequency furthermore identical illustrate implementation importantly in vivo inclusion indicates indirect individual inhomogeneous institute inter intra iterations knowledge largely leads library literature macromolecular many matched materials measured metabolite metabolites mimic noise normalized nulled original otherwise overlap particularly persisting placed plank pool press prior profit projection proposed quantification quantify quantitative random randomly realistic receive reduce reduces represent reproducibility resembles resolved revised sampled scaling sets severe shape shortcomings simple simulated situations smith smoothed software spectra spectral spectroscopy spectrum spline spreading stable starting stay steps subject subsequently system taken thoroughly together tool transmit true typical validated variations various version virtual visual widths