Meeting Banner
Abstract #2038

Localization Profile Correction for ERETIC Based in Vivo 1H MRSI Quantification

Niklaus Zoelch1, Alexander Fuchs1, Anke Henning2, 3

1Institue for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland; 2Institue for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 3Max Planck Institue for Biological Cybernetics, Tbingen, Germany

ERETIC is a calibration method independent of the disease state, automatically compensates for changes in coil loading conditions and hence requires only a one time calibration against a high precision phantom. However, when ERETIC is used for the quantification of MRSI images, the combined effect of B1+ inhomogeneity across the volume of interest and slice profiles of the selective RF pulses used for localization need to be corrected for. In this work two approaches of this correction are presented and validated against internal water referencing.

Keywords

abbreviated accomplished accounts accurate acquisition actual alternative analytically another applied appropriate automatically axial band bandwidth basis bingen biological biomedical birdcage blue border brain calibration carried chemical choice clearly coefficients coil combined compensate compensates concentration concentrations conditions convolving correct corrected correction corrections correspond coupled cross described determination disease diseases distribution effective electrical encoding engineering errors every excitation expected experimental externally field fissure fitted fitting formula gain gradient gray healthy helms hence henning highly human implementation imposes in vivo inaccuracies included inconsistencies independent induces inhomogeneity initial inner intensities intensity localization magnetization maps material materials matrix measured metabolite metabolites modifications normalization observable overlap partial pass phantom physiological plotted precision preselected press previously profile pulse pulses quantification quantitative receive recorded rectangular referencing reflect refocusing regarding relevant reliable scaled scanner segmentation settings simply simulated simulation slice smoothed source spectra spectral spectroscopic stack subset superior suppression tissue transition validated variation variations varying vitro volume volumes volunteer water white whole