Impaired Pyruvate Carboxylase and Pentose Phosphate Pathway in APP-PS1 Mouse Model of Alzheimers Disease

Keywords

account acids activity addition administered amino anesthetized anion arising biology biotechnology blood brain carbon carbons cellular characterized cognitive column common control cycle deficits depicts disease disordered disorders earlier energy enormous evaluates exchange excitatory exhibit explored extract extracted extracts fasted fate flow flux fluxes forms fraction fractions frozen functions funding glucose glutamate government hardy human impaired impairment important incorporates indicate indicates indicating infused infusion inhibitory intensity internal investigate label labeling labels late loading major marked matched materials measured memory metabolism metabolites metabolized mice model molecular month mouse natl neuronal neurons neurotransmitters numerous overnight oxidation passing pathology pathway pathways percent phosphate plaque positions preliminary progression progressive reduced reduction respectively science separated significantly situ source spectral spectroscopy spectrum stage supported terminal tissue together urethane