Meeting Banner
Abstract #1969

in vivo Investigation of Choline Compounds with 1H and 31P MRS in the Patients with Liver Disorders.

Martin Gajdosik1, Ladislav Valkovic1, Marek Chmelik1, Stefan Traussnigg2, Michael Trauner2, Siegfried Trattnig1, Martin Krssk, 13

1MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Vienna, Austria; 2Gastroenterology & Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; 3Endocrinology & Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

The measurements of choline containing compounds in the liver lack the clean conclusion. In this study the link between 1H & 31P MR spectroscopy (MRS) regarding to choline containing compound and hepatic lipids in patients with liver disorders - non-alcoholic fatty liver disease and steatohepatitis was examined. The MRS measurements allowed to resolve the resonances of choline containing metabolites and we could find certain links between proton and phosphorus MRS derived measures of hepatic metabolism status.

Abstract PDF Poster PDF

Keywords

according alcoholic allowed array assessed biomedical biopsy body cell certain changing choline circular cirrhosis clean coefficient coil compounds concentration considered containing contamination content contribute correction correlated correlation correlations degradation derived detail detailed diagnosed disorders double either eleven enables endocrinology energy even examined example excellence expected fatty females fibrosis field find fitted grading hepatic histological histology in vivo included inorganic internal intracellular investigation lack larger linear link links lipid liver males martin measured measures median medical medicine membrane metabolism metabolites minimal needed nucleotide obesity observation package partly patient patients peak phosphate phosphorus precursors press processed products radiology rapid regarding removed resolve resolved resonant respective scanner score selected seven significantly spectra spectroscopic spectroscopy spine staging status strength strong substances sufficient suppression surface suspicion though tissue tissues turnover understanding useful variables water whereas world