Neuronal and Astroglial Metabolism in APP-PS1 Mouse Model of Alzheimer's Disease with Progress of Age

Keywords

absolute acetate acids activity amino anesthetized animal appearance approved biology biotechnology blood brain carried cellular cerebral clinical closely cognitive committee concentrations constraint control cortex cortical currently cycling deficit determination determined diagnosis disease dysfunction early either enhanced enrichment ethics evaluate exhibit extracted extracts fasted finding fitting flow fluxes focus frozen function functions funding glucose glutamate government hardy head impaired impairment in vivo indicate indicates indicating infused infusion institutional labeled labeling late loss match matched materials measured memory metabolic metabolism metabolites mice model molecular month mouse natl neuronal neurons neurotransmitter nitrogen objective overnight oxidation pathology percent plaque potential precedes profile progress progression progressive proliferation protocols quantitative reduced remains science significantly situ spectroscopy spectrum steady substrates suggesting supported symptoms synaptic tail tissue together turnover type unaltered unperturbed urethane vein viability whereas wild