7 T 1H MRS Detects a Human Brain Glutathione (GSH) Response to N-Acetylcysteine, an Antioxidant Precursor, in Patients with Gaucher and Parkinsons Disease

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achieved acknowledgments acquisition action administration alleviate allowed although always amelioration among antioxidant antioxidants basis blood bore brain compound computed concentration conditions consideration consistent contribution controlled corrected cortex course delay delivery design detect detected detects development disease dosage dosing eddy efficacy elliptical evaluating every expected experimental field formation foundation gaucher guide half head healthy hour human hypotheses hypothesis illustrated important individual infusion intermediate internal intracellular intravenous intravenously laser lead least males mart mass maximal measure measured mechanism metabolites minutes modified modulated monitor needed occipital occurred optimal oxidative paired participant patients peak peaked pertinent plotting poised poorly position post potent precursor prior profile protocol protocols quality quantification quantified regimens reliably remove residual responds response return safety saved scanned scanner selected semi sensitive serve several shims shot spectra spectrometry start status stress strong subject subjects sufficient suggests therapeutic throughout transceiver translated treatment treatments trials typical ultra understand update utility utilized volume volumes water years