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Abstract #1911

Natural D-Glucose as a Biodegradable T2 Contrast Agent for MRI

Nirbhay N. Yadav1, 2, Jiadi Xu1, 2, Amnon Bar-Shir3, 4, Qin Qin1, 2, Peter C.M. van Zijl1, 2

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States; 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 4The Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

We show that natural D-glucose can be used as an exogenous T2 relaxation agent, particularly at field strengths available for human MRI. Transverse relaxation and diffusion measurements were carried out on D-glucose phantoms at different concentrations, pH, and magnetic field strengths (3 T and 7 T). The results show strong dependence of water transverse relaxivity on glucose concentration, sample pH, and field strength. We show the increased relaxivity is due to the 5 exchangeable hydroxyl protons in glucose and that the greatest relaxivity is observed in the physiological pH range.

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