Meeting Banner
Abstract #1895

Au@Gd Core-Shell Nanoparticles as a CT/MR Bimodal Contrast Agent

Min-Kyoung Kang1, Hee-Kyung Kim1, Ki-Hye Jung2, Ji-Ae Park3, Seung-Tae Woo4, Joo-Hyun Kim4, Eun-Young Jeon5, Tae-Jeong Kim2, Yongmin Chang1, 6

1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea; 2Applied Chemistry, Kyungpook National University, Daegu, Korea; 3Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science, Seoul, Korea; 4Bayer Healthcare, Medical care, Seoul, Korea; 5The Advanced Medical Technology Cluster for Diagnosis & Prediction, Kyungpook National University, Daegu, Korea; 6Diagnostic Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea

Gold/gadolinium core-shell nanoparticles of the formula Au@SiO2@Gd@PEG were synthesized for use as a CT/MR bimodal contrast agent. The preparation initially requires the formation of Au@SiO2 through self-condensation of TEOS on the surface of AuNPs. Au@SiO2 thus formed was dispersed in aqueous alcohol to react with Gd(NO3) 3 in the presence of urea, leading to the formation of Au@SiO2@Gd core-shell nanoparticles. In order to increase solubility as well as biocompatibility further coated with PEG. These systems reveal both high CT attenuation and MR relaxivities (R1 = 13.01 mM-1sec-1) so may be put into entry a new class of CT/MR bimodal imaging probes.

Abstract PDF

Keywords

absorbing absorption according adapted addition advanced agent agents almost although among application attenuation attractive become bimodal biological blood brighter brightest candidate care carried chelate chemistry citrate class clearance cluster commercial computed concentration concentrations contains contrast core cost currently describes determined development diagnosis diagnostic effective employed enable engineering entry examine exhibits expected experimental feasibility features finally five formulated frequency functions gadolinium gaining gill give gold good herein highest highly illustrated instrumental intensity inversion iodinated iodine kidney known least linear literature many maps material measured medical medicine microanalysis modalities modified molecular molecules mostly myriad national novel organ others park phantom pixel plots pool possess potential prediction prepared principle probe probes processed pulse purchased radiological radiology ranging rapid rays reagents received recent recovery represent respectively reveal scales scheme science serious shell short shortcomings sources spin squares stability strong studies substitute surface synthesis system table targeting technology terms tomography unit variable versatile volume widely young