Meeting Banner
Abstract #1879

DO3A-Benzothiazole Conjugates for Use as Gd-Based Theragnostic Agents

Hee-Kyung Kim1, Ki-Hye Jung2, Min-Kyoung Kang1, Ji-Ae Park3, Eun-Young Jeon4, Seung-Tae Woo5, Joo-Hyun Kim5, Tae-Jeong Kim2, Yongmin Chang1, 6

1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea; 2Applied Chemistry, Kyungpook National University, Daegu, Korea; 3Molecular Imaging Research Center, Korea Institute of Radiological & Medical Science, Seoul, Korea; 4The Advanced Medical Technology Cluster for Diagnosis & Prediction, Kyungpook National University, Daegu, Korea; 5Bayer Healthcare, Medical Care, Seoul, Korea; 6Diagnostic Radiology and Molecular Medicine, Kyungpook National University, Daegu, Korea

DO3A-benzothiazole conjugates have been prepared as a new family of multifunctional MRI/optical imaging probes with concomitant antitumor activity as well as tumor-specificity. Its R1 relaxivity is 3.84 mM-1sec-1, almost the same values as that of structurally related Dotarem&[reg]. The pattern of in vivo MRI enhacement compares well with those of liver-specific MRI CAs. More characteristically, it is to be noted that excretion is made via bile duct, confirming hepatobiliary uptake. T1-weighted MR images of MCF-7 cells incubated with Gd-DO3A-BT, revealing the tumor-specificity of the present series. In addition, antitumor activity of the present system represented as GI50 and TGI values.

Abstract PDF

Keywords

abdominal ability acquisition activity added addition agents almost analytical applications bile biological breast buffer cancer capture care cause cell cells centrifuged channel characteristically characterization chemotherapy clinical coil commercial complex complexes compounds concomitant confirming conjugates containing contrast coronal cultured deal diagnosis diagnostic dishes distinguish drawn enhanced enhancement example excretion family fast field gadolinium growth harvested home in vivo incubated incubation inhibition injection inner intensity inversion investigation investigations knee known least length linear long made material matrix measured media medical medicine medium mice molecular national nature needed neutron noted optical ovarian oxygen paramagnetic park pattern plated post potential powerful prominent properties radiological radiology reagents received receiver recovery regard related removed removing repetition resolution scheme science select series serum slice soft solution solvent sources spatial specifically specificity spectroscopic spin square stained studies synthesis synthesized system table tail targeting technology therapeutic therapy toward train transferred trypsin tube tumor type unit variable various vein view vitro washed young