Meeting Banner
Abstract #1869

SPIO-Loaded Unilamellar Polyion Complex Vesicles (SPIO-Cy5-PICsomes) as a High Relaxivity Contrast Agent for Tumor Detection

Daisuke Kokuryo1, Yasutaka Anraku2, Akihiro Kishimura2, Sayaka Tanaka3, Mitsunobu R. Kano4, Nobuhiro Nishiyama3, Tsuneo Saga1, Ichio Aoki1, Kazunori Kataoka2, 3

1Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; 2Graduate School of Engineering, The University of Tokyo, Tokyo, Japan; 3Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 4Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

A newly developed SPIO-loaded and fluorescence dye (Cy5)-labeled polyion complex nanocarrier, termed SPIO-Cy5-PICsome, composed of two biocompatible oppositely charged block copolymers was applied to evaluate its ability to detect small tumors with MRI. In vitro r2 of the SPIO-Cy5-PICsomes was 2.54 times higher than that of free ferucarbotran. In in vivo experiments using subcutaneously xenografted mice, MR signal from the tumor changed during the 3 hours after SPIO-Cy5-PICsome administration. A small tumor was also detected at 24 hours after administration. SPIO-Cy5-PICsomes are a powerful nanocarrier with the potential to detect small and early-stage tumor for early diagnosis.

Abstract PDF

Keywords

accumulation acid acquisition administration advice agent amino another applications approved around arrows assistance authors bearing biomedical block bloodstream bore caliper cancer captured cells charged chem circulation clinical coil colon complex composed concentration confirm connected contrast control controlled cross days decreased dentistry dependence detect detected detection diffusion early efficacy engineered engineering enhanced equal equip especially ethyl ethylene evaluate evaluated evaluation expanded experiment facilitated field five fluorescence future graduate homo hours illustrates improving in vivo influence injected inside intravenous iron japan larger linking loaded magnet mapping materials matrix measured medicine metastatic mice mixed mixer model molecular molecules mouse named necessary next novel occurred oppositely oxide paper paramagnetic patient photo polymers potential powerful predominantly preparation prepared previously probably program prolonged prolonging promoting radiological rapidly recognition release reported representation retention saga school sciences sensitive significantly slice solution stage stirred studies system target technical thought transplantation transverse treatment tumor tumors unit vesicle vesicles vessels vitro volume white yang