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Abstract #1828

Treatment of Staphylococcus Aureus Induced Abscesses Via Magnetic Resonance Guided Focused Ultrasound

David Bates1, 2, Birgit Rieck1, Laura Curiel1, 3, Samuel Pichardo1, 3

1Thunder Bay Regional Research Institute, Thunder Bay, Ontario, Canada; 2Biology, Lakehead University, Thunder Bay, Ontario, Canada; 3Department of Electrical and Computer Engineering, Lakehead University, Thunder Bay, Ontario, Canada

MR-guided focused ultrasound was investigated as a mode of treatment for subcutaneous murine Staphylococcus aureus abscesses. High and moderate temperature ultrasonication of the abscess centre were investigated, with high temperature (65&#730;C) demonstrating a significantly reduced (p<.05) bacterial concentration with respect to control four days post-treatment. Neither level of treatment was shown to increase inflammation over the baseline elevated abscess activity, suggesting innate immune system sparing.

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Keywords

abscess abscesses acquisition activity altering animal applications applied audience bacterial bates biology capable clinicians communication computer concentration concentrations conditions conducted considered control coronal counting days delivered determined developed disease done effective efficacy electrical elevating elevation engineering equivalent estimation excised experimental exposures female focal focused frequency gantry guided highly hours house immune inaccessibly indicates induced infection infections infectious injected innate institute instruments kinetic laura length load localized located management matrix measure mice moderate novel occurred often planning plate post precise prior produces proton real reconstruction recruitment reducing reduction regional resistant respect response responsive routine scientists seeking significantly skin slice sparing spectrophotometric staphylococcus subcutaneous subcutaneously suspension system target temperature thermal thunder tissue toolkit transducer transformed transverse treated treatment treatments ultrasound untreated water