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Abstract #1666

MRI Visualization of Local Drug Delivery

Morgan Giers1, Qingwei Liu2, Ken Schmidt3, Gregory H. Turner2, Alex McLaren3, Michael Caplan4, Ryan Mclemore3

1School of biological and health Systems Engineering, Arizona State University, Tempe, AZ, United States; 2Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 3Orthopaedic Residency, Banner Good Samaritan Medical Center, Phoenix, AZ, United States; 4Harrington Bioengineering Department, Arizona State University, Tempe, AZ, United States

In this study, we have developed an imaging-based technique, using a gadolinium-marked small molecule, for monitoring the distribution of locally delivered antimicrobial from bone cement in extremity wounds that will enable real time analysis of drug concentration and adjustment of clinical management.

Keywords

acquisition address adjusted agent amount anesthesia antibiotics antimicrobials appreciated around aspect assays avoid banner bioengineering biological biopsies biopsy blood body bone carefully cement clinical closed closure concentration concentrations considerable contrast control controlled created dead delivered delivery dense detect developed deviation direct distributed distribution drug duration enable engineering every experiment experimental fascia femur final fitting fluid full furthermore gadolinium good health heart histogram hours immediately implant importantly in vivo incision increasing indicates infection intervals intramuscular issue knowledge limited loaded local locally majority management maps marked mass minute minutes mixed model monitoring muscle neurological open overlap oxygen partial phoenix plus practical prepared previously prior procedure protocol quadriceps rabbits ranging rare release relevance remained removing repetition residency samples scanner school segmented septa series severe simplex site skin space spaces spatial statistically suffer suggesting surgery surgical surrounding systems taken temperature temporal threshold tissue traditional turner usable variation varies vehicles vessel visible visualized volume white wound wounds year