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Abstract #1634

Progression of Fatty Infiltration After Muscle Inflammation in FSH Muscular Dystrophy

Barbara H. Janssen1, Nicoline B.M. Voet2, Alexander C. Geurts2, George W. Padberg3, Baziel G. van Engelen3, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2rehabilitation, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands

Fascioscapulohumeral muscular dystrophy (FSHD) is one of the most common neuromuscular dystrophies. As in other muscular dystrophies inflammation is suspected to play a key role in the progression of muscle dysfunction. To study the role of inflammation in FSHD we performed a qualitative and quantitative assessment of TIRM and T1 weighted images collected at baseline and after a control period of four months. We found an increase in signal intensity of the T1 weighted images (i.e.; increased fatty infiltration) in muscles with early inflammation (i.e; hyperintensities on TIRM).

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Keywords

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