Meeting Banner
Abstract #1582

Measurement of Tissue Extracellular Volume in Health and Amyloidosis Using Equilibrium Contrast MRI

Steve Bandula1, Sanjay Banypersad2, Daniel Sado2, Stuart Taylor1, Shonit Punwani1, James Moon2

1Centre for Medical Imaging, University College London, London, United Kingdom; 2The Heart Hospital, University College London Hospital , London, United Kingdom

Equilibrium MRI (EQ-MRI) is a new technique that can quantify extracellular volume fraction and has been used to measure diffuse myocardial fibrosis. In this study, EQ-MRI is utilized to define the extracellular volume within healthy abdominal organs and demonstrate a significant increase in tissue ECV in patients with amyloidosis a disease defined by extracellular deposition of abnormal proteins.

Abstract PDF Poster PDF

Keywords

abdominal abnormal according accumulate accurately alternative assessed becomes biceps biological biopsy blood bolus breath cardiovascular cause chest circulating circulation college complication component condition consent contrast corrected curves deposition determined diagnosis diagnostic difficult diffuse disease diseases drawn equilibrium ethics evaluate evaluation example expanded expansion extracellular fast fibrosis field flash formula fraction frequently giving gradient health healthy heart hold hospital human humans increasing increments informed infusion intensity interstitial invasive inversion kingdom known lancet lavender liver local measure measured median medical minutes moon muscle muscles myers myocardial myocardium occurs organs overall particularly patients plotted population preliminary primed principles procedures protein proteins quantify radionuclide recovery repeat respectively restored risk serum shot slice slices spleen spoiled statistically subjects subsequently systemic targeting technically tissue tissues underwent upper utilize validation variation view volume volunteers wide