Meeting Banner
Abstract #1547

Prediction and Assessment of Response to Renal Artery Revascularization with Dynamic Contrast-Enhanced MRI: A Pilot Study

Su Wei Lim1, Constantina Chrysochou2, David L. Buckley1, Philip A. Kalra2, Steven Sourbron1

1University of Leeds, Leeds, Yorkshire, United Kingdom; 2Department of Renal Medicine, Salford Royal Hospital, Salford, Greater Manchester, United Kingdom

The purpose of this study is to assess the potential of DCE-MRI measurements of renal function and perfusion to predict and evaluate functional outcome after renal artery revascularization in humans. 16 patients with renal artery stenosis underwent DCE-MRI and radioisotope measurement of single-kidney GFR at baseline, and 4 months after revascularization. Results show that DCE-MRI has the potential to replace radioisotopes for planning and follow-up of renal artery revascularisation, and may improve patient selection through the additional information on vascularity. Specifically, the data suggest that well-vascularised kidneys with low extraction fractions are most likely to benefit.

Abstract PDF

Keywords

additional agrees artery assess assessed assessment basis benefit better bland blood broadly card characterization comparing confidence contrast defined derive detect deteriorate deteriorated disease distal divided dynamic enhanced evaluate extraction fact failure filtration flow fraction fractions function functional future greater hospital humans identifying improve improved increasing indicates injury insufficient intern interval intervention intra invest isotope isotopes kidney kidneys kingdom latter likely limited materials measures medicine minority monitoring months motivation need outcome patient patients perfusion pilot planning post potential power predict prediction predictive preserved procedure produced prognostic quantitative radioisotope radioisotopes reduced renal replace response risks royal selection severity significance specifically stable statistical strong studies suggests supported table therapy trends tubular underwent volume white