Imaging Impaired Gas Uptake in a Rat Model of Pulmonary Fibrosis with 3D Hyperpolarized 129Xe MRI

Keywords

accumulated achieve acquisition active allowing alveolar animals approved arrows assess audience axial barrier birdcage blood bore breath breaths capillary cells challenging chemical clear coil concepts condition console contrast control coronal days delay denote depicting described detected determined diffuses diffusion dimensions directly disease displayed displays dissolved distributed distribution dramatically duke employed exchange excised excite exploited extended feasible fibrosis fisher gaseous gases generate glover histology homogeneously human impaired impairment in vivo induced instillation instruments interstitial longitudinally lung lungs magnet matrix mechanically medical metabolically microscopy mixture model moderately modified moreover needed noninvasive oxford plasma polarizer possesses prepared previously procedures properties prototype pulmonary quadrature quantify radial rats reduce reduced regardless regional respectively saline scheme sensitive separately separation serve slices soluble spectral spectroscopically subjects suggesting surrogate target thickening thrall throughout tissue tissues transit treated treatment unilateral untreated uptake variable variant vehicle ventilated ventilation views white