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Abstract #1407

High Resolution Myocardial T1 Mapping Using MOLLI with Parallel Imaging and Compressed Sensing

Xiao Chen1, Bhairav B. Mehta1, Michael Salerno2, 3, Frederick H. Epstein1

1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Medicine, University of Virginia, Charlottesville, VA, United States; 3Radiology, University of Virginia, Charlottesville, VA, United States

Modified Look-Locker Imaging (MOLLI) is routinely used for T1 mapping of the left ventricle. High resolution MOLLI requires fast imaging to remain free of artifacts due to cardiorespiratory motion. The combination of parallel imaging and compressed sensing (CS) has been used to accelerate cardiac cine and perfusion imaging but not MOLLI. We developed an algorithm that combines parallel SENSE and CS kt-Sparsity and Low Rank (kt-SLR) and applied it to accelerate MOLLI to achieve high resolution (1.21.2 mm2) T1 mapping using a standard breathhold clinical protocol (17 heartbeats).

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Keywords

accelerate accelerated acceleration accuracy accurate achieve achieved acquisition agreement among applied array artifacts association audience award background biomedical blood breath cardiac channel channels chest cine clinical clinicians coil collected combination combined combines compressed correlations decomposition detailed developed deviation deviations engineering estimation example excellent exploit fast free frequency fully funded good heart heartbeats hold implemented included indicating induced inversion iterative lists locker look mainly mapping maps medical medicine merged model modified motion myocardial myocardium noise overall parallel partial perfusion predoctoral preserved proposed protocol quality quantified radiology randomly rank reconstructed reconstruction reduce remain remove removed represent requires researchers resembled resolution routinely sample sampled scanner sense sensing sensitivity singular soft solutions space sparsity spatial structures table targeted threshold thresholding utilizing ventricle volunteers window