Meeting Banner
Abstract #1383

Cardiac Structure and Function Are Altered in Adults with Non-Alcoholic Fatty Liver Disease with No Known Cardiac Involvement

Kieren Grant Hollingsworth1, Kate Hallsworth2, Christian Thoma2, Djordje G. Jakovljevic2, Guy A. MacGowan3, Quentin Anstee1, Andrew M. Blamire1, Roy Taylor1, Chris P. Day1, Michael I. Trenell2

1Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 2MOVElab, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom; 3Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, Tyne and Wear, United Kingdom

Non-alcoholic fatty liver disease (NAFLD) is associated with a twofold greater risk of developing cardiovascular disease than those witout. Little is known about the early cardiac alterations in NAFLD, limiting our ability to identify therapeutic strategies. This study aimed to define the effect of NAFLD on cardiac morphology, function and metabolism in a representative group of 19 subjects using MRI imaging, cardiac tagging and phosphorus spectroscopy. NAFLD patients had significantly thicker LV walls, with reduced longitudinal shortening. Peak torsion was unaltered but peak strain at the endocardial wall was increased. PCr/ATP ratio was not reduced, unlike the previous young male study.

Abstract PDF Poster PDF

Keywords

address affected aged aimed alcoholic altered although apex approval arises audience axis blood body bottom cardiac cardiovascular care characteristics cine circumferential clinical clinically cohorts coil concentric contamination contrast control controls corrected cycle decrease decreases defining despite detected developing diabetes diabetic diastole diastolic disease efficiency ejection encoding energetics excitation fasting fatty findings function future gender generated glucose heart history hypertrophy index individual informed institute involvement kingdom known lean limiting lipid liver longitudinal major mass matched measure measured medicine metabolism morphological morphology muscle myocardial needed nineteen obesity occur output oxygen patients peak plasma pool population predicting preferentially pressure previously profile protocol quantification relatively representative rider risk saturation sense shear short shortening since skeletal spacing spatial spectroscopy status strain strategies stroke structure studies subjects substantial suggests surface systole systolic table tagging taken target terms thanks thick thickening throughout torsion triglyceride triglycerides trust turbo twofold type unaffected upon variations volume volumes wall wear young younger