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Abstract #1353

Cerebrovascular Compliance Quantification with Non-Gated, Velocity Encoded Projections

Zachary Rodgers1, Michael C. Langham1, Jeremy F. Magland1, John A. Detre2, Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Neurology, University of Pennsylvania, Philadelphia, PA, United States

A non-gated method for quantification of cerebrovascular compliance (CVC) the change in volume (ΔV) divided by change in pressure (ΔP) of brain microvasculature over the cardiac cycle is presented. Dual-slice interleaved velocity encoded projections provide simultaneous measurement of cerebral inflow and outflow waveforms continuously at 30 ms resolution for quantification of ΔV. Projection-based CVC produced similar waveform shapes and ΔV values compared to retrospectively gated PC-MRI in about 1/10th the scan time and without gating, greatly reducing potential errors due to temporal averaging. The method could be applied to better understand the vascular contribution to diseases such as Alzheimers.

Keywords

accurately acquisition address advantage allow alternative applied applying arrows arterial arteries averaging axial background band blood blue brain capture cardiac carotid central cerebral compliance consecutive consecutively considerably contribution critical cuff cycle cycles dampening demonstrating despite development diagram disease divided encoded equal especially evidence feasibility flow fully function furthermore future gated gating gives gold grant half head heart identical immediately impact inflow initial injury integrating interleaves internal intra invasive investigate investigation investigations limitation limited location locations maps marker measured must near neck negative oblique offer otherwise outflow overlap overly peak pilot positive potential precision pressure prevent previous probing produce produces prognosis progression projection projections prospectively pulse quantification quantified quantifying reduced represents required requires resolve resolving retrospectively robust saturation selected shape sharpness significantly similarity sinus slice stack steady studies subject subjects sufficient suggests superior support surprisingly temporal tenth thought traumatic unlike unsteady velocity venous vertebral vessels viability volume wave waveform waveforms whether young