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Abstract #1344

Comparison of MRI and US Assessment of Vascular Reactivity in Relation to CVD Risk Factors in Old and Young Healthy Subjects

Erica Chirico1, Michael C. Langham, Erin K. Englund, Susan Schultz1, Lifeng Zhang2, Sandy Sehgal1, Emile R. Mohler2, Felix W. Wehrli

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Medicine, Cardiovascular Division, Vascular Medicine Section, University of Pennsylvania, Philadelphia, PA, United States

We evaluated an integrated MRI protocol that consists of three quantitative techniques against established ultrasound (US) measures: flow-mediated dilation (FMD) of brachial artery and intima-media thickness (IMT) of carotid arteries. MRI techniques included dynamic velocimetry and oximetry in femoral artery and vein, respectively, and regional quantification of pulse-wave velocity in the aortic arch, thoracoabdominal aorta and iliofemoral arteries. The subjects consisted of healthy young and old without a history of cardiovascular disease. Initial results indicate that age-related decline in vascular reactivity are characterized by both MRI and US.

Keywords

accelerated achieve acknowledgment aging among aorta aortic arch arrow arterial arteries artery assessed assessment bifurcation blood blue brain cardiovascular carotid central challenge characterized coil consisting course cuff decreased derived desaturated descending diameter dilation disease duration dynamic dysfunction elapsed endothelial errors essentially evaluate every exciting expected femoral fern flow forward frequencies gating hand healthy history hyperemia iliac immune include index indicate indicated indicators indirectly induced inflammation internal lead locations lumen magnitude mapping marker matrix measured measures media mediated medicine minute monitored needed oblique observe occlusion overshoot oxygen paradigm part parts peak peripheral physiological pressure prior projection protocol proximal pulse quantification quantified quantify quantifying quantitative reactive reactivity real recorded recovery regional relation release represent representative represents resolution respectively response risk roman sample sandy saturation section segments similarly simultaneously sites slice slices statistically studies subjects successive systolic table temporal temporary terms traditional transient transit trend upslope vascular vein velocity venous washout wave waveform young