Meeting Banner
Abstract #1342

Semi-Automated Pulse Wave Velocity Measurement in the Thoracic Aorta Using 4D Flow MRI

Bruce S. Spottiswoode1, Aurelien F. Stalder2, Mehmet Gulsun3, Michael Markl4, 5

1Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States; 2Magnetic Resonance, Imaging & Therapy, Healthcare Sector, Siemens AG, Erlangen, Germany; 3Siemens Corporation, Corporate Technology, Princeton, NJ, United States; 4Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States; 5Department of Biomedical Engineering, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Pulse wave velocity (PWV) has been shown to be a reliable surrogate marker for cardiovascular disease. In this work, we described a method for automatically estimating PWV from 4D flow data after manually prescribing only the start and end points of the vessel. High temporal resolution 4D and 2D phase contrast flow data of the thoracic aorta were acquired in 9 healthy volunteers. The PWV derived from 4D and 2D flow data were in agreement with each other and with the literature, and sub sampling to a more typical temporal resolution had the effect of reducing the PWV estimates.

Abstract PDF Poster PDF

Keywords

acceleration acquisition additional ages agreement aims aorta aortic applied approval ascending assess assessment atherosclerosis audience automated automatically biomedical blue bull cardiovascular catheter cause centerline circulation compliance consent contours contrast coordinates corporate corporation correlation correspond corresponds coverage curve curves custom derived descending detection directional disease distal distance divided early encoding engineering evaluation events expected extracted extracting extraction fast fitted fitting flow fold foundation frames full gated global good grant hundred identified imported increasing informed initiative intensive jersey labor least limited literature longitudinal lumen made manually marker measure measured measuring medicine memorial meta moderate mortality navigator needs nine northwestern orientation plot predictor proximal pulse radiologists radiology rapid recent reconstructed reliable researchers resembled resolution respectively robust sampling scanned scanner school sector segmentation segmenting semi sense slopes spatial square stiffness support system systolic target technology temporal therapy thoracic timing tool translational upslope validate velocity vessel volumetric volunteers wave waveform waveforms years