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Abstract #1193

fMRI Evidence of Increasing Disengagement of Sustained Attention-Related Activation with Increasing Age in ADHD Children

Brianne Mohl1, Dhruman Goradia1, Dalal Khatib1, Rachel Dick1, Caroline Zajac-Benitez1, Usha Rajan1, Olivia McGarragle1, Arthur L. Robin1, David R. Rosenberg1, Vaibhav A. Diwadkar1, Jeffrey A. Stanley1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

ADHD is a serious public health problem. We recently reported age-related biochemical deficits in the prefrontal cortex of ADHD children using in vivo 31P MRS suggesting a lack of a progressive neurodevelopment in ADHD children. However, the functional basis of this effect has not been investigated using fMRI. The purpose of this study was to investigate whether ADHD children would show a similar lack of age-related changes in sustained attention performance. We hypothesized that healthy children will show an age-related increase in the fMRI BOLD response to attention performance, which will be absent in ADHD children.

Keywords

acquisition activation activity adolescents altered analyses anterior appear assessed assessment attention attentional axial background basal behavioral blocked boxcar button canonical channel characterized children cluster clusters coil collecting college combined context contrast contrasted contrasts control convolved core correlation cortex covariance covariate covariates cross decreases demonstrations developing developmental diagnostic dick digits disengagement disorder dorsal dynamics epochs evidence excessive extension findings forms free frontal functional ganglia gender general gradient half head hour hypothesize impulse included increasing indicate individuals inference inferior instructed interacting interactions kernel lack least likewise linear lobe matrix maturation medical medication medicine model modeled movement negative network networks normalization novel opposite paradigm parietal particular performance period perspective predominantly preprocessed press previous prior protocol providing psychiatry psycho pure realignment reflecting regarding related response rest resting robin rotation school sectional series significance slices smoothing specifically structural studies subjects suggestive supporting susceptibility sustained system target task thresholded trajectories translation type typically volume volumes ward wave