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Abstract #1186

Disrupted Topological Organization of White Matter Structural Networks in Bipolar Disorder

Fuchun Lin1, Shenhong Weng2, Baojun Xie3, Yunfei Zha3, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences, Wuhan, Hubei, China; 2Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, Hubei, China; 3Department of Radiology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China

Network analysis method was used to investigate the architecture of the white matter structural networks bipolar disorder. Although bipolar patients showed a small-world organization of white matter networks, they had significantly decreased network strength, decreased global efficiency and increased shortest path length. Moreover, bipolar patients had reduced efficiencies in several parietal, temporal, frontal, occipital and limbic regions. These findings may improve our understanding of the potential mechanisms of the underlying neurobiological basis of bipolar disorder.

Keywords

abnormalities absolute academy acquisition advances affect affecting alterations although anatomical angst angular architecture atomic automatic basic basis bipolar brain characteristics china clustering coefficient collinear common connected connections connectivity control controls corrected cortex decreased defined despite disorder disrupted distribution distributions edge efficiencies efficiency eighteen endpoints evaluate evidence expressed fiber fibers findings foundation frontal general global gong gradient grant grants graph health healthy hospital hypothesized illness increasing inferior integrity investigate involved known laboratory length limbic little lobe local localize located mainly males materials mathematics matrix measures mechanisms medial median middle molecular morbidity mortality native natural network networks neural ninety nodal node nodes normalized occipital organization parietal part participant path patients physics population potential problem program psychiatric psychiatry psychopathology radiology reconstruct reduced regional represents role sample science sciences several shared significantly sixteen slice statistical strength structural structurally subject subjects suggests superior symmetric system template temporal topological unclear uncorrected underlying understanding white whole world years