Meeting Banner
Abstract #1153

Primary Olfactory Cortex Involvement in Alzheimers Disease: A Functional and Morphological MRI Investigation

Megha Vasavada1, Jian-Li Wang1, Xiaoyu Sun1, Sarah Ryan1, Christopher Weitekamp1, Prasanna Karunanayaka1, Qing Yang1

1Penn State University, Hershey, PA, United States

Olfactory deficits are known to occur in patients with Mild Cognitive Impairment (MCI) and early AD. In this work, we performed concurrent measurements of the volumes and olfactory activations of the primary olfactory cortex (POC) and hippocampus, and demonstrated that the POC is clearly involved in early AD functionally and pathologically.

Keywords

acknowledgments activated activation adding administered affected affecting aging alone already among analyze anatomical appeared appears asked assistance behavioral beta better black blood bold brain button clinical cognitive cognitively collected collecting common comparable controls correlate correlation cortex cure cycles decrease decreases decreasing degeneration dementia dependent diagnosis diagnostic disease dynamic earliest early even every evidence examine examined examining excellent females form functional funding future gender greater green hypothesized identification impaired important include includes indicated individual individuals investigation involved involvement larger lavender learn literature lobe longitudinal looking loss manifestations manually many marker markers medial mild million morphological morphology must namely neocortex network networks neural occur odor olfactory oxygen paradigm pathology patients plaques population positive potential press primary prism progressed progression prompt psychiatry pure reach respond scanner scores screen segmented significance significantly slope slowing smell smelled specifically stages statistical stimulus structures studies subject subjects tangles temporal underlay understanding unlocking utilizing visual volume volumes volumetric years