Meeting Banner
Abstract #1107

Hippocampal Volume Relates to White Matter Integrity and Episodic Memory in Multiple Sclerosis

Katherine A. Koenig1, Ken E. Sakaie1, Mark J. Lowe1, Jian Lin1, Lael Stone2, Robert A. Bermel3, Erik B. Beall1, Stephen M. Rao2, Bruce D. Trapp4, Micheal D. Phillips1

1Imaging Sciences, Cleveland Clinic, Cleveland, OH, United States; 2Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; 3Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States; 4Neurosciences, Cleveland Clinic, Cleveland, OH, United States

The current study compares hippocampal atrophy to episodic memory measures and to diffusion measures of the fornix in patients with Multiple Sclerosis. Though we find no differences in overall hippocampal volume between patients and controls, measures of white matter integrity in the fornix and a measure of episodic memory were related to hippocampal volume only in patients. This bolsters the argument that hippocampal pathology contributes to memory loss in MS.

Abstract PDF Poster PDF

Keywords

abilities according accuracy acquisitions addition approved argument assessment atrophy audience automated bilateral bilaterally bolsters brain burden checked clinic cognitive coil completed contributes control controls corporation corrected correction correlate correlated correlation correlations created decreased degree delis density deviations diffusion disease disorder efferent episodic expect expert fell focused formula fraction function gray greater head healthy hypothesized identified impairment included individual institute integrity iterative largest library loss male manually mark masks matrix measure measures memory molecular motion neurological outside overall pathology patient patients performance program protocol psychological reached receive recent reduce related relates relationship relatively removed researchers resources role sample scanned sciences sclerosis scores several significance significantly slices software stone subject subjects synaptic table target tensor thick though tract trained underlie unpaired verbal volume volumes volumetric white