Meeting Banner
Abstract #1065

Changes in Connectivity Associated with Neuronal Migration Disorder as Assessed by Diffusion Tractography

Emi Takahashi1, Glenn D. Rosen2, Allison C.R. Scott3, Veronica J. Peschansky2, Natsuko Fujisaki2, Guangping Dai4, Patricia Ellen Grant5, Albert M. Galaburda2

1Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; 2Beth Israel Deaconess Medical Center, Boston, MA, United States; 3Columbia University, New York, NY, United States; 4Massachusetts General Hospital, Boston, MA, United States; 5Boston Children's Hospital, Boston, MA, United States

The goal of this study is to use non-invasive diffusion weighted imaging and tractography to develop a quantifiable and verifiable biomarker of neuronal migration disorder. Our results suggest that the number and volume of identified tractography pathways were significant predictors of neuronal migration disorders in callosum and intra-hemispheric pathways. The length of tractogrpahy pathways was also a significant predictor of the disorders in the total and intra-hemispheric pathways. These experiments clearly support the notion that there are profound changes in the nature of connectivity associated with disruption of neuronal migration.

Keywords

acquisition agent aimed analyses anatomical angular animal anisotropy anterior apparent applied approximately assessed audience behavioral beth brain brains candidate cerebral children clearly code coding coefficient color condition connectivity consequences construct containing contrast control cortex cortical deaconess develop developmental differed diffusion disorder disorders disruption disruptions dyslexia either evidence expression fiber fitting fixed fractional function gadolinium gene general genetic goal grant greater hairpin hemisphere hemispheres hemispheric hospital hours identified important insights intra invasive knocking length measured measures medical middle migration model modeling modulation mutant nature neuronal notion orientation pathways perfused phenotype physiological placed planar plasmids post posterior predictor predictors profound quantifiable rats recent reconstruct reconstructed repeated resolution scanned school scrambled session shorter significantly sixty solution spatial spin spinal statistically suggest suggests support susceptibility system target tensor threshold toolkit usual vector vectors verifiable veronica visualize volume whole wide