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Abstract #1041

Using Volumetric Measures of Neuroanatomy to Cluster Multiple Mouse Models of Autism.

Jacob Ellegood1, R Mark Henkelman1, 2, Jason P. Lerch1, 2

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

This work takes an expansive approach in order to identify the similarities and differences in neuroanatomy across the autistic spectrum. To this end, we examined 20+ mouse models of ASD candidate genes using high resolution structural MRI.

Keywords

abridged absolute accounts acquisition affected align allow allowed alto analyses anatomical arch autism autistic background basis biophysics brain brains candidate cerebellum child children clinical cluster clustered clustering collaboration commonly communication complex connection control corpus correlation currently date deficits despite detailed discovered disorders disparate distinct echoes either examined expansive explain fast field findings gene genes genotype giving groupings help heritable heterogeneous hierarchical highlight highly hospital human identify importantly in vivo included individual isotropic knockout known laboratory labs larger mark matrix measures medical mice mixture model models mouse neuroanatomy note objectives overlap packer pixel poorly population presentations previously psychiatry quite regional registration repetitive resolution saving scanned segregated sick similarities skulls smaller social solely space spectrum spin still structural syndrome take throughput together type unchanged understood unexpectedly variability version view volumes volumetric whole wild