Meeting Banner
Abstract #0970

Effects of Age on Brain Tumour Metabolite Levels Measured by In-Vivo 1H MRS in Children and Young People Are Tumour Type Specific

Nigel Paul Davies1, 2, Simrandip Gill2, 3, Lesley MacPherson3, Theodoros N. Arvanitis4, Andrew C. Peet2, 3

1Imaging & Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, West Midlands, United Kingdom; 2Cancer Sciences, University of Birmingham, Birmingham, West Midlands, United Kingdom; 3Birmingham Children's Hospital NHS Foundation Trust, Birmingham, West Midlands, United Kingdom; 4School of Electronic, Electrical & Computer Engineering, University of Birmingham, Birmingham, West Midlands, United Kingdom

MRS metabolite profiles are useful for characterising brain tumours. Clinical, histopathological and genetic features vary between brain tumours at different ages in children and adults. However, it is not known whether these differences manifest as variations in tumour metabolite levels with age. This study investigates metabolite level differences and correlations with age across a cohort of childhood brain tumours (N=243). The only significant correlation after Bonferroni correction was between choline and age for medulloblastomas (N=42). This finding could not be explained by differences in maturation, metastatic status, gender or histopathological subtype; hence the potential association with genetic subtype should be investigated.

Abstract PDF

Keywords

accounting adolescent adult aggressiveness although among apparently applied associations biological brain cancer cell characteristics childhood children choline classic clear clinical cohort common comparing components computer confirmation considerable consistent control correction correlation correlations correspondence criteria cubic define detailed diagnosed diagnoses diagnosis distribution electrical electronic engineering enhancing even explained exploration features female formal foundation furthermore gender genetic genetics gill giving glycine hospital hospitals in vivo independent invasive investigated investigation kingdom knowledge known larger link lipid macromolecular made male males malignant management manifest march maturation measured medical meeting metabolite metabolites metastatic midlands molecular months moreover oncology overlap parametric part patients peak people physics placed potential preponderance press primary profile prognosis prognostic quality radiological reported required resolution retrieval reveal reviews role scanners school sciences short side significantly solid source spectral spectroscopy status stratification structural studies subsequently subtype subtypes successful suggests treatment triangles trust type types useful variation variations vary volume warranted water west whether whole years young