Meeting Banner
Abstract #0932

Sexual Dimorphism in the Human Corpus Callosum After Controlling for Brain Size

Babak A. Ardekani1

1Center for Advanced Brain Imaging, The Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States

A number of studies have reported that, "relative to brain size," the mid-sagittal corpus callosum cross-sectional area (CCA) in females is on average larger than in males. However, others suggest that these may be spurious differences created in the CCA-to-brain-size ratio because brain size tends to be larger in males. To help resolve this controversy, we measured the CCA on structural MRI scans of normal young adults (n=74, 37 males, 18-29 years), matched closely for brain size, from the OASIS (Open Access Series of Imaging Studies) cross-sectional dataset. Females had a significantly larger CCA (P<0.0005).

Keywords

accessible addition adult adults advanced ages aligned analyses analyzed anterior approximately assume atlas atlases attributed authors automated automatic automatically availability aware bishop brain brains came capacity close closely community completely confirm contended controlling corpus correcting covariance covariates cross database debate decline decrease defined dependent detected differ dimorphism domain easily evidence expected facilitate female females fixed fully gender generally greater hand head hitherto hoped human implementation included independently investigating keep landmarks larger linear located longstanding made male males many matched matrix meta minute model none noting oasis original overlap pace pairs paper peters pixel post power process projects psychiatric public publicly question rage reason recent rectangular refuted regardless registration relatively resolving roll said scanner science scientific search sectional segmentation segmentations select serial sexual significance significantly slice sliced software speed statistical structural studies subjects substantial suggested suggesting surprisingly takes tendency third toolbox transparent true variable vision volume volumes whatever whose windows workstation young