Meeting Banner
Abstract #0922

Non-Invasive Regional Brain Temperature Measurements During and After Hypothermia Therapy in Newborns with Suspected Hypoxic/ischemic Brain Injury

Tai-Wei Wu1, Ida Ashoori2, 3, Jessica L. Wisnowski2, Marvin D. Nelson2, Thomas G. Perkins4, Jonathan M. Chia4, Ashok Panigrahy5, Stefan Blml2, 3

1Neonatology, Children's Hospital Los Angeles, Los Angeles, CA, United States; 2Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States; 3Rudi Schulte Research Institute, Santa Barbara, CA, United States; 4Philips Healthcare, Cleveland, OH, United States; 5Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States

This study uses non-invasive MR spectroscopy to measure regional brain temperatures during and after hypothermia therapy (HT) in newborns with suspicion for hypoxic ischemic encephalopathy. The goal of the study was to determine whether HT is effective in lowering brain temperature, to explore regional differences, and to determine to what extent esophageal/rectal temperatures correlate with brain temperatures. The long-term goal is to use this information to tailer HT to the needs of individual patients.

Abstract PDF Poster PDF

Keywords

accurately achieved acknowledgment actual addition aged aiding appropriate approved asphyxia assess assessed assessing basal best birth body brain calibration care chemical children clinical compatible consistent continuously control controls cooling core currently decreased deemed determine determined differ directly dissociation eight employed encephalopathy equipment esophageal evolving examined example extent findings foundation ganglia generally goal hospital hours hypothermia in vivo indistinguishable individual infants injury instead institute intensive invasive knowledge known lactate larger local measured metabolism model monitored monitoring nelson neonates newborn newborns outcome overall parietal patient patients patterns peak perinatal poor poorer post preliminary press probe radiology rectal reflect regional retrospective review several significantly slightly software solution spectra spectroscopy spectrum student studies subjects suffering suspected suspicion system tailoring temperature temperatures tentatively therapeutic therapy toward trend unremarkable unsuppressed varied versus warmer warming water years